Properties
Description
BIBW2992 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (L858R), EGFR (L858R/T790M), EGFR (wt), and HER2.
Molecular Formula
C24H25ClFN5O3
Targets
EGFR (L858R): 0.4 nM; EGFR (L858R/T790M): 10 nM; EGFR (wt): 0.5 nM; HER2: 14 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
BIBW2992 (Afatinib) is used to inhibit EGFR and HER2, useful in clinical cancer research.
