Properties
Description
BIBW2992 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (L858R), EGFR (L858R/T790M), EGFR (wt), and HER2.
Molecular Formula
C24H25ClFN5O3
Targets
EGFR (L858R): 0.4 nM; EGFR (L858R/T790M): 10 nM; EGFR (wt): 0.5 nM; HER2: 14 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
BIBW2992 (Afatinib) is used to inhibit EGFR and HER2, useful in clinical cancer research.
