EGFR-HER2 inhibitor Canertinib dihydrochloride, Purity ≥98%

Synonym: Canertinib dihydrochloride; 289499-45-2; Canertinib HCl; Canertinib (dihydrochloride); CI-1033; Canertinib 2HCl; EGFR-HER2 inhibitor

MDL: MFCD09954112
CAS Number: 289499-45-2
Compound CID: 156413

Product Size

50 mg; 100 mg; 250 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Canertinib dihydrochloride, soluble in DMSO and water and insoluble in ethanol, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR and ErbB2.

Molecular Weight

558.86

Molecular Formula

C₂₄H₂₇Cl₃FN₅O₃

Targets

EGFR: 7.4 nM; ErbB2: 9 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (157.46 mM); Water: 18 mg/mL (32.2 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Canertinib dihydrochloride can be used to irreversibly inhibit EGFR family members for oncology research.