EGFR-HER2 inhibitor Canertinib dihydrochloride, Purity ≥98%

Synonym: Canertinib dihydrochloride; 289499-45-2; Canertinib HCl; Canertinib (dihydrochloride); CI-1033; Canertinib 2HCl; EGFR-HER2 inhibitor

MDL: MFCD09954112
CAS Number: 289499-45-2
Compound CID: 156413

Product Size

50 mg; 100 mg; 250 mg; 500 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Canertinib dihydrochloride, soluble in DMSO and water and insoluble in ethanol, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR and ErbB2.

Molecular Weight

558.86

Molecular Formula

C₂₄H₂₇Cl₃FN₅O₃

Targets

EGFR: 7.4 nM; ErbB2: 9 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 88 mg/mL (157.46 mM); Water: 18 mg/mL (32.2 mM); Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Canertinib dihydrochloride can be used to irreversibly inhibit EGFR family members for oncology research.

Storage

Store at -20ºC.