EGFR-HER2 inhibitor Canertinib, Purity ≥98%

Synonym: Canertinib; 267243-28-7; CI-1033; PD-183805; Canertinib free base; N-(4-(3-Chloro-4-fluorophenylamino)-7-(3-morpholinopropoxy)quinazolin-6-yl)acrylamide; N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-[3-(morpholin-4-yl)propoxy]quinazolin-6-yl}prop-2-enamide; EGFR-HER2 inhibitor

CAS Number: 267243-28-7
Compound CID: 156414

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Canertinib, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR and ErbB2.

Molecular Weight

485.9

Molecular Formula

C₂₄H₂₅ClFN₅O₃

Targets

EGFR: 1.5 nM; ErbB2: 9.0 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 2 mg/mL (4.11 mM); Water: Insoluble; Ethanol: 8 mg/mL (16.46 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Canertinib is employed to investigate its inhibitory effects on EGFR family kinases in cancer studies.