Properties
Description
CO-1686, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR(L858R)/T790M and EGFRT790M.
Molecular Formula
C27H28F3N7O3
Targets
EGFR(L858R)/T790M: 21.5 nM (Ki); EGFRT790M: 303.3 nM (Ki)
Solubility
DMSO: 91 mg/mL (163.8 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
CO-1686 can be used to study its efficacy as a mutant-selective EGFR inhibitor, especially in non-small cell lung cancer.
