Properties
Description
EGF816, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR(L858R/T790M).
Molecular Formula
C26H31ClN6O2
Targets
EGFR(L858R/T790M): 31 nM (Ki)
Solubility
DMSO: 92 mg/mL (185.85 mM); Water: Insoluble; Ethanol: 92 mg/mL (185.85 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
EGF816 is applied in research focusing on its selective inhibition of EGFR mutant forms in cancer therapies.
