Properties
Description
EGF816, soluble in DMSO and ethanol and insoluble in water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR(L858R/T790M).
Molecular Formula
C26H31ClN6O2
Targets
EGFR(L858R/T790M): 31 nM (Ki)
Solubility
DMSO: 92 mg/mL (185.85 mM); Water: Insoluble; Ethanol: 92 mg/mL (185.85 mM)
Identity
Confirmed by NMR/HPLC/MS.
Applications
EGF816 is applied in research focusing on its selective inhibition of EGFR mutant forms in cancer therapies.
