Properties
Description
Epertinib hydrochloride, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, HER2 and HER4.
Molecular Formula
C30H28Cl2FN5O3
Targets
EGFR: 1.48 ± 0.0 nM; HER2: 7.15 ± 0.5 nM; HER4: 2.49 ± 0.1 nM
Solubility
DMSO: 88 mg/mL (147.53 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Epertinib hydrochloride can be utilized to investigate its dual inhibitory roles on EGFR and HER2 in oncology research.
