EGFR-HER2 inhibitor Gefitinib, Purity ≥98%

Synonym: Gefitinib; 184475-35-2; Iressa; ZD1839; Irressat; N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-morpholinopropoxy)quinazolin-4-amine; EGFR-HER2 inhibitor

MDL: MFCD04307832
CAS Number: 184475-35-2
Compound CID: 123631

Product Size

100 mg; 250 mg; 500 mg; 1000 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Gefitinib, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets Tyr1173 (NR6W cells), Tyr1173 (NR6wtEGFR cells), Tyr992 (NR6W cells), and Tyr992 (NR6wtEGFR cells).

Molecular Weight

446.9

Molecular Formula

C₂₂H₂₄ClFN₄O₃

Targets

Tyr1173 (NR6W cells): 26 nM; Tyr1173 (NR6wtEGFR cells): 37 nM; Tyr992 (NR6W cells): 57 nM; Tyr992 (NR6wtEGFR cells): 37 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 80 mg/mL (179 mM); Water: Insoluble; Ethanol: 4 mg/mL (8.95 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Gefitinib is employed to investigate its effects as an EGFR inhibitor in various cancer models.