EGFR-HER2 inhibitor Lapatinib ditosylate, Purity ≥98%

Synonym: Lapatinib Ditosylate; 388082-77-7; Tykerb; Tykerb Ditosylate; Lapatinib (ditosylate); Lapatinib (GW-572016) Ditosylate; EGFR-HER2 inhibitor

MDL: MFCD09264195
CAS Number: 388082-77-7
Compound CID: 9941095

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lapatinib ditosylate, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB4, c-Fms, and C-Raf-1.

Molecular Weight

925.46

Molecular Formula

C₄₃H₄₂ClFN₄O₁₀S₃

Targets

EGFR: 10.8 nM; ErbB4: 367 nM; c-Fms: >10 μM; C-Raf-1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (100.49 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Lapatinib ditosylate can be used to inhibit both EGFR and HER2 (ErbB2) in cancer research.

Storage

Store at -20ºC.