EGFR-HER2 inhibitor Lapatinib ditosylate, Purity ≥98%

Synonym: Lapatinib Ditosylate; 388082-77-7; Tykerb; Tykerb Ditosylate; Lapatinib (ditosylate); Lapatinib (GW-572016) Ditosylate; EGFR-HER2 inhibitor

MDL: MFCD09264195
CAS Number: 388082-77-7
Compound CID: 9941095

Product Size

25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lapatinib ditosylate, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB4, c-Fms, and C-Raf-1.

Molecular Weight

925.46

Molecular Formula

C₄₃H₄₂ClFN₄O₁₀S₃

Targets

EGFR: 10.8 nM; ErbB4: 367 nM; c-Fms: >10 μM; C-Raf-1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (100.49 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Lapatinib ditosylate can be used to inhibit both EGFR and HER2 (ErbB2) in cancer research.