EGFR-HER2 inhibitor Lapatinib (free base), Purity ≥98%

Synonym: Lapatinib; 231277-92-2; Lapatinib ditosylate; Tykerb; GW572016; GW 572016; Lapatinib [INN]; EGFR-HER2 inhibitor

MDL: MFCD09264194
CAS Number: 231277-92-2
Compound CID: 208908

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lapatinib (free base), soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB4, c-Fms, and C-Raf-1.

Molecular Weight

581.1

Molecular Formula

C₂₉H₂₆ClFN₄O₄S

Targets

EGFR: 10.8 nM; ErbB4: 367 nM; c-Fms: >10 μM; C-Raf-1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 99 mg/mL (170.37 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Lapatinib (free base) can be used to inhibit EGFR and HER2 in cancer therapy research.

Storage

Store at -20ºC.