EGFR-HER2 inhibitor Lapatinib (free base), Purity ≥98%

Synonym: Lapatinib; 231277-92-2; Lapatinib ditosylate; Tykerb; GW572016; GW 572016; Lapatinib [INN]; EGFR-HER2 inhibitor

MDL: MFCD09264194
CAS Number: 231277-92-2
Compound CID: 208908

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lapatinib (free base), soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB4, c-Fms, and C-Raf-1.

Molecular Weight

581.1

Molecular Formula

C₂₉H₂₆ClFN₄O₄S

Targets

EGFR: 10.8 nM; ErbB4: 367 nM; c-Fms: >10 μM; C-Raf-1: >10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 99 mg/mL (170.37 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Lapatinib (free base) can be used to inhibit EGFR and HER2 in cancer therapy research.