EGFR-HER2 inhibitor Mubritinib, Purity ≥98%

Synonym: Mubritinib; 366017-09-6; Mubritinib (TAK 165); TAK 165; TAK-165; TAK165; (E)-4-((4-(4-(1H-1,2,3-triazol-1-yl)butyl)phenoxy)methyl)-2-(4-(trifluoromethyl)styryl)oxazole; EGFR-HER2 inhibitor

MDL: MFCD09954135
CAS Number: 366017-09-6
Compound CID: 6444692

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Mubritinib, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, FGFR, BLK, and HER2/ErbB2.

Molecular Weight

468.5

Molecular Formula

C₂₅H₂₃F₃N₄O₂

Targets

EGFR: >25 μM; FGFR: >25 μM; BLK: >25 μM; HER2/ErbB2: 6.0 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (25.61 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Mubritinib can be used to inhibit HER2/ErbB2 for research into HER2-positive cancers.

Storage

Store at -20ºC.