EGFR-HER2 inhibitor Neratinib, Purity ≥98%

Synonym: Neratinib; 698387-09-6; HKI-272; Neratinib (HKI-272); Nerlynx; HKI 272; UNII-JJH94R3PWB; EGFR-HER2 inhibitor

MDL: MFCD09752958
CAS Number: 698387-09-6
Compound CID: 9915743

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Neratinib, soluble in warmed DMSO and insoluble in water and ethanol, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, KDR, Akt, and c-Met.

Molecular Weight

557

Molecular Formula

C₃₀H₂₉ClN₆O₃

Targets

EGFR: 92 nM; KDR: 800 nM; Akt: >20 μM; c-Met: >35 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 4 mg/mL (7.18 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Neratinib can be used to irreversibly inhibit HER2 and EGFR for research into HER2-positive breast cancer.