EGFR-HER2 inhibitor Neratinib, Purity ≥98%

Synonym: Neratinib; 698387-09-6; HKI-272; Neratinib (HKI-272); Nerlynx; HKI 272; UNII-JJH94R3PWB; EGFR-HER2 inhibitor

MDL: MFCD09752958
CAS Number: 698387-09-6
Compound CID: 9915743

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Neratinib, soluble in warmed DMSO and insoluble in water and ethanol, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, KDR, Akt, and c-Met.

Molecular Weight

557

Molecular Formula

C₃₀H₂₉ClN₆O₃

Targets

EGFR: 92 nM; KDR: 800 nM; Akt: >20 μM; c-Met: >35 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 4 mg/mL (7.18 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Neratinib can be used to irreversibly inhibit HER2 and EGFR for research into HER2-positive breast cancer.

Storage

Store at -20ºC.