EGFR-HER2 inhibitor OSI-420, Purity ≥98%

Synonym: OSI-420; 183320-51-6; Desmethyl Erlotinib; CP-473420; 2-[4-(3-Ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol; EGFR-HER2 inhibitor

CAS Number: 183320-51-6
Compound CID: 18924996

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

OSI-420, soluble in warmed DMSO and insoluble in water and ethanol, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR.

Molecular Weight

415.9

Molecular Formula

C₂₁H₂₁N₃O₄.HCl

Targets

EGFR: 2 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 75 mg/mL (180.34 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

OSI-420 can be used as a metabolite of erlotinib to inhibit EGFR in cancer research.