EGFR-HER2 inhibitor Osimertinib dimesylate, Purity ≥98%

Synonym: 2070014-82-1; EGFR-HER2 inhibitor; AZD-9291; AZD9291; AZD 9291 (dimesylate); Mereletinib (dimesylate)

CAS Number: 2070014-82-1
Compound CID: 92044416

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Osimertinib dimesylate is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (L858R) and EGFR (L858R/T790M).

Molecular Weight

691.82

Molecular Formula

C₃₀H₄₁N₇O₈S₂

Targets

EGFR (L858R): 12 nM (enzyme assay); EGFR (L858R/T790M): 1 nM (IC₅₀, enzyme assays)

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

EGFR-HER2 inhibitor Osimertinib dimesylate is utilized for its ability to irreversibly inhibit EGFR mutations and HER2, aiding in researching treatment options for non-small cell lung cancer.