Properties
Description
PD158780 is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR, ErbB2, ErbB3, and ErbB4.
Molecular Formula
C14H12BrN5
Targets
EGFR: 8 μM; ErbB2: 49 nM; ErbB3: 52 nM; ErbB4: 52 nM
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
PD158780 can be used to study its function as an EGFR tyrosine kinase inhibitor in cancer cell signaling.
