EGFR-HER2 inhibitor Pelitinib, Purity ≥98%

Synonym: Pelitinib; 257933-82-7; EKB-569; Pelitinib (EKB-569); WAY-EKB 569; EKB 569; 326894-84-2; EGFR-HER2 inhibitor

MDL: MFCD09837868
CAS Number: 257933-82-7
Compound CID: 6445562

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pelitinib, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets MEK/ERK, Src, c-Met, and CDK4.

Molecular Weight

467.9

Molecular Formula

C₂₄H₂₃ClFN₅O₂

Targets

MEK/ERK: 800 nM; Src: 282 nM; c-Met: 4.1 μM; CDK4: >20 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (25.64 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Pelitinib can be used to irreversibly inhibit EGFR for oncology research.

Storage

Store at -20ºC.