EGFR-HER2 inhibitor Pelitinib, Purity ≥98%

Synonym: Pelitinib; 257933-82-7; EKB-569; Pelitinib (EKB-569); WAY-EKB 569; EKB 569; 326894-84-2; EGFR-HER2 inhibitor

MDL: MFCD09837868
CAS Number: 257933-82-7
Compound CID: 6445562

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pelitinib, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets MEK/ERK, Src, c-Met, and CDK4.

Molecular Weight

467.9

Molecular Formula

C₂₄H₂₃ClFN₅O₂

Targets

MEK/ERK: 800 nM; Src: 282 nM; c-Met: 4.1 μM; CDK4: >20 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (25.64 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Pelitinib can be used to irreversibly inhibit EGFR for oncology research.