EGFR-HER2 inhibitor PF299804, Purity ≥98%

Synonym: Dacomitinib; 1110813-31-4; PF-00299804; PF299804; Dacomitinib (PF299804, PF299); (E)-N-(4-((3-Chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide; Dacomitinib anhydrous; EGFR-HER2 inhibitor

MDL: MFCD19443734
CAS Number: 1110813-31-4
Compound CID: 11511120

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF299804, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and ErbB4.

Molecular Weight

469.9

Molecular Formula

C₂₄H₂₅ClFN₅O₂

Targets

EGFR: 6.0 nM; ErbB2: 45.7 nM; ErbB4: 73.7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 17 mg/mL (36.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF299804 (Dacomitinib) can be used to inhibit EGFR and HER2 for cancer research.