EGFR-HER2 inhibitor PF299804, Purity ≥98%

Synonym: Dacomitinib; 1110813-31-4; PF-00299804; PF299804; Dacomitinib (PF299804, PF299); (E)-N-(4-((3-Chloro-4-fluorophenyl)aMino)-7-Methoxyquinazolin-6-yl)-4-(piperidin-1-yl)but-2-enaMide; Dacomitinib anhydrous; EGFR-HER2 inhibitor

MDL: MFCD19443734
CAS Number: 1110813-31-4
Compound CID: 11511120

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF299804, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, and ErbB4.

Molecular Weight

469.9

Molecular Formula

C₂₄H₂₅ClFN₅O₂

Targets

EGFR: 6.0 nM; ErbB2: 45.7 nM; ErbB4: 73.7 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 17 mg/mL (36.17 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PF299804 (Dacomitinib) can be used to inhibit EGFR and HER2 for cancer research.

Storage

Store at -20ºC.