EGFR-HER2 inhibitor PKC 412, Purity ≥98%

Synonym: Midostaurin; PKC412; 120685-11-2; Benzoylstaurosporine; Cgp 41251; PKC-412; 4'-N-Benzoylstaurosporine; EGFR-HER2 inhibitor

MDL: MFCD00871372
CAS Number: 120685-11-2
Compound CID: 9829523

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PKC 412, soluble in DMSO and warmed ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets PKCβ1, PKCγ, c-FGR, and c-Lyn.

Molecular Weight

570.64

Molecular Formula

C₃₅H₃₀N₄O₄

Targets

PKCβ1: 30 nM; PKCγ: 24 nM; c-FGR: 790 nM; c-Lyn: 4.30 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (157.72 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

PKC 412 (Midostaurin) can be used to inhibit multiple kinases, including PKC and FLT3, for cancer research.

Storage

Store at -20ºC.