EGFR-HER2 inhibitor PKC 412, Purity ≥98%

Synonym: Midostaurin; PKC412; 120685-11-2; Benzoylstaurosporine; Cgp 41251; PKC-412; 4'-N-Benzoylstaurosporine; EGFR-HER2 inhibitor

MDL: MFCD00871372
CAS Number: 120685-11-2
Compound CID: 9829523

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PKC 412, soluble in DMSO and warmed ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets PKCβ1, PKCγ, c-FGR, and c-Lyn.

Molecular Weight

570.64

Molecular Formula

C₃₅H₃₀N₄O₄

Targets

PKCβ1: 30 nM; PKCγ: 24 nM; c-FGR: 790 nM; c-Lyn: 4.30 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 90 mg/mL (157.72 mM); Water: Insoluble; Warmed ethanol: 18 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

PKC 412 (Midostaurin) can be used to inhibit multiple kinases, including PKC and FLT3, for cancer research.