EGFR-HER2 inhibitor Poziotinib, Purity ≥98%

Synonym: 1092364-38-9; HM781-36B; NOV120101; NOV-120101; NOV 120101; EGFR-HER2 inhibitor

CAS Number: 1092364-38-9
Compound CID: 25127713

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Poziotinib, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets HER1, HER2, and HER4.

Molecular Weight

491.34

Molecular Formula

C₂₃H₂₁Cl₂FN₄O₃

Targets

HER1: 3.2 nM; HER2: 5.3 nM; HER4: 23.5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 84 mg/mL (170.96 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Poziotinib is investigated in research exploring its broad activity as an irreversible EGFR/HER2 inhibitor in various cancers.