Properties
Description
Poziotinib, soluble in DMSO and insoluble in ethanol and water, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets HER1, HER2, and HER4.
Molecular Formula
C23H21Cl2FN4O3
Targets
HER1: 3.2 nM; HER2: 5.3 nM; HER4: 23.5 nM
Solubility
DMSO: 84 mg/mL (170.96 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
Poziotinib is investigated in research exploring its broad activity as an irreversible EGFR/HER2 inhibitor in various cancers.
