EGFR-HER2 inhibitor SU-5402, Purity ≥98%

Synonym: 215543-92-3; su5402; SU-5402; SU 5402; 3-[(3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-YL)METHYLENE]-2-INDOLINONE; 3-[4-Methyl-2-[(Z)-(2-oxo-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl]propanoic acid; EGFR-HER2 inhibitor

CAS Number: 215543-92-3
Compound CID: 5289418

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

SU-5402, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets FGFR1, PDGFRβ, and VEGFR2.

Molecular Weight

296.32

Molecular Formula

C₁₇H₁₆N₂O₃

Targets

FGFR1: 30 nM; PDGFRβ: 510 nM; VEGFR2: 20 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 54 mg/mL (182.23 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

SU-5402 can be used to inhibit receptor tyrosine kinases including FGFR, VEGFR, and PDGFR in cancer research.

Storage

Store at -20ºC.