EGFR-HER2 inhibitor TAK-285, Purity ≥98%

Synonym: TAK-285; 871026-44-7; TAK285; TAK 285; N-(2-(4-((3-Chloro-4-(3-(trifluoromethyl)phenoxy)phenyl)amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl)ethyl)-3-hydroxy-3-methylbutanamide; EGFR-HER2 inhibitor

MDL: MFCD22124520
CAS Number: 871026-44-7
Compound CID: 11620908

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TAK-285, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR/HER1, HER4, ASK1, and AuroraB.

Molecular Weight

548

Molecular Formula

C₂₆H₂₅ClF₃N₅O₃

Targets

EGFR/HER1: 23 nM; HER4: 260 nM; ASK1: >10 μM; AuroraB: 1.7 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 97 mg/mL (177.02 mM); Water: Insoluble; Ethanol: 48 mg/mL (87.59 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

TAK-285 can be used to study the inhibition of HER2 and EGFR in cancer research.

Storage

Store at -20ºC.