EGFR-HER2 inhibitor Tyrphostin AG 879, Purity ≥98%

Synonym: Tyrphostin AG 879; 148741-30-4; AG 879; AG-879; AG879; alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide; Tyrphostin Ag-879; EGFR-HER2 inhibitor

CAS Number: 148741-30-4
Compound CID: 135419190

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Tyrphostin AG 879, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, HER2-Neu, PDGFR, and Trk.

Molecular Weight

316.5

Molecular Formula

C₁₈H₂₄N₂OS

Targets

EGFR: >500 μM; HER2-Neu: 1.0 μM; PDGFR: >100 μM; Trk: 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 35 mg/mL (110.59 mM); Water: Insoluble; Ethanol: 3 mg/mL (9.47 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Tyrphostin AG 879 is employed to inhibit ErbB2 receptor tyrosine kinase, relevant in cancer studies.

Storage

Store at -20ºC.