EGFR-HER2 inhibitor Tyrphostin AG 879, Purity ≥98%

Synonym: Tyrphostin AG 879; 148741-30-4; AG 879; AG-879; AG879; alpha-Cyano-(3,5-di-t-butyl-4-hydroxy)thiocinnamide; Tyrphostin Ag-879; EGFR-HER2 inhibitor

CAS Number: 148741-30-4
Compound CID: 135419190

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Tyrphostin AG 879, soluble in DMSO and ethanol and insoluble in water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, HER2-Neu, PDGFR, and Trk.

Molecular Weight

316.5

Molecular Formula

C₁₈H₂₄N₂OS

Targets

EGFR: >500 μM; HER2-Neu: 1.0 μM; PDGFR: >100 μM; Trk: 10 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 35 mg/mL (110.59 mM); Water: Insoluble; Ethanol: 3 mg/mL (9.47 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Tyrphostin AG 879 is employed to inhibit ErbB2 receptor tyrosine kinase, relevant in cancer studies.