EGFR-HER2 inhibitor WHI-P 154, Purity ≥98%

Synonym: WHI-P154; 211555-04-3; WHI-P 154; jak3 inhibitor ii; 2-Bromo-4-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol; 2-Bromo-4-((6,7-dimethoxyquinazolin-4-yl)amino)phenol; 2-Bromo-4-[(6,7-dimethoxy-4-quinazolinyl)amino]phenol; EGFR-HER2 inhibitor

MDL: MFCD02179366
CAS Number: 211555-04-3
Compound CID: 3795

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

WHI-P 154, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, JAK3, Src, and VEGFR.

Molecular Weight

376.2

Molecular Formula

C₁₆H₁₄BrN₃O₃

Targets

EGFR: 4 nM; JAK3: 1.8 nM; Src: 100 nM; VEGFR: 100 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 74 mg/mL (196.7 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

WHI-P 154 can be used to study JAK3 inhibition in the context of immune response modulation.

Storage

Store at -20ºC.