EGFR-HER2 inhibitor WZ3146, Purity ≥98%

Synonym: 1214265-56-1; WZ3146; WZ-3146; N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide; EGFR-HER2 inhibitor

CAS Number: 1214265-56-1
Compound CID: 44607360

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

WZ3146, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (E746_A750), EGFR (E746_A750/T790M), EGFR (L858R), and EGFR (L858R/T790M).

Molecular Weight

465

Molecular Formula

C₂₄H₂₅ClN₆O₂

Targets

EGFR (E746_A750): 2 nM; EGFR (E746_A750/T790M): 14 nM; EGFR (L858R): 2 nM; EGFR (L858R/T790M): 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (178.51 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

WZ3146 can be used to inhibit mutant EGFR (T790M) for drug resistance research in cancer.

Storage

Store at -20ºC.