EGFR-HER2 inhibitor WZ3146, Purity ≥98%

Synonym: 1214265-56-1; WZ3146; WZ-3146; N-(3-((5-Chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)oxy)phenyl)acrylamide; EGFR-HER2 inhibitor

CAS Number: 1214265-56-1
Compound CID: 44607360

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

WZ3146, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (E746_A750), EGFR (E746_A750/T790M), EGFR (L858R), and EGFR (L858R/T790M).

Molecular Weight

465

Molecular Formula

C₂₄H₂₅ClN₆O₂

Targets

EGFR (E746_A750): 2 nM; EGFR (E746_A750/T790M): 14 nM; EGFR (L858R): 2 nM; EGFR (L858R/T790M): 5 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (178.51 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

WZ3146 can be used to inhibit mutant EGFR (T790M) for drug resistance research in cancer.