EGFR-HER2 inhibitor WZ4002, Purity ≥98%

Synonym: WZ4002; 1213269-23-8; WZ-4002; N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; EGFR-HER2 inhibitor

CAS Number: 1213269-23-8
Compound CID: 44607530

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

WZ4002, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (L858R) (BaF3 cells) and EGFR (L858R/T790M) (BaF3 cells).

Molecular Weight

495

Molecular Formula

C₂₅H₂₇ClN₆O₃

Targets

EGFR (L858R) (BaF3 cells): 2 nM; EGFR (L858R/T790M) (BaF3 cells): 8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (24.28 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

WZ4002 can be used to inhibit mutant EGFR (T790M) and help in studying resistance mechanisms in cancer therapy.

Storage

Store at -20ºC.