EGFR-HER2 inhibitor WZ4002, Purity ≥98%

Synonym: WZ4002; 1213269-23-8; WZ-4002; N-(3-(5-Chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; EGFR-HER2 inhibitor

CAS Number: 1213269-23-8
Compound CID: 44607530

Product Size

10 mg; 25 mg; 50 mg; 100 mg; 200 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

WZ4002, soluble in DMSO and insoluble in ethanol and water, is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR (L858R) (BaF3 cells) and EGFR (L858R/T790M) (BaF3 cells).

Molecular Weight

495

Molecular Formula

C₂₅H₂₇ClN₆O₃

Targets

EGFR (L858R) (BaF3 cells): 2 nM; EGFR (L858R/T790M) (BaF3 cells): 8 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 12 mg/mL (24.28 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

WZ4002 can be used to inhibit mutant EGFR (T790M) and help in studying resistance mechanisms in cancer therapy.