Properties
Description
XL647 is a potent and specific inhibitor of the tyrosine kinase activity of EGFR. It targets EGFR, ErbB2, Flt-4, and KDR.
Molecular Formula
C24H27Cl2FN4O2
Targets
EGFR: 0.3 nM; ErbB2: 16 nM; Flt-4: 8.7 nM; KDR: 1.5 nM
Identity
Confirmed by NMR/HPLC/MS.
Applications
XL647 can be used to study the inhibition of multiple receptor tyrosine kinases, including EGFR, HER2, and VEGFR2, in cancer.
