Properties
Description
EGFR inhibitor, soluble in DMSO, water and ethanol, is a compound that blocks the activity of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), both of which are involved in driving the growth and proliferation of certain types of cancer cells. It targets EGFR (WT), EGFR (L858R), EGFREGFR(L861Q), and HER4.
Molecular Formula
C21H18F3N5O
Targets
EGFR (WT): 21 nM; EGFR (L858R): 63 nM; EGFREGFR(L861Q): 4 nM; HER4: 7640 nM
Solubility
DMSO: 79 mg/mL (191.09 mM); Water: <1 mg/mL; Ethanol: 2 mg/mL (4.83 mM)
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
EGFR inhibitor is a general term for compounds used to block EGFR activity in various cancer research studies.
