Properties
Description
ABBV-744, soluble in DMSO and insoluble in ethanol and water, disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD2 (BD2), BRD3 (BD2), BRD4 (BD2), BRD4 (BD2), and BRDT (BD2).
Molecular Formula
C28H30FN3O4
Targets
BRD2 (BD2): 8 nM; BRD3 (BD2): 13 nM; BRD4 (BD2): 4 nM; BRD4 (BD2): 3 nM; BRDT (BD2): 18 nM
Solubility
DMSO: 94 mg/mL (191.22 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Stability
The product is stable for three years when stored at the recommended temperature in lyophilized powder.
Applications
ABBV-744 is utilized to study the selective inhibition of the BET family of bromodomains, particularly in the context of therapeutic applications in cancer.
