Epigenetic reader domain inhibitor ABBV-744, Purity ≥98%

Synonym: 2138861-99-9; ABBV 744; ABBV744; Epigenetic reader domain inhibitor

CAS Number: 2138861-99-9
Compound CID: 132010322

Product Size

2 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

ABBV-744, soluble in DMSO and insoluble in ethanol and water, disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD2 (BD2), BRD3 (BD2), BRD4 (BD2), BRD4 (BD2), and BRDT (BD2).

Molecular Weight

491.55

Molecular Formula

C₂₈H₃₀FN₃O₄

Targets

BRD2 (BD2): 8 nM; BRD3 (BD2): 13 nM; BRD4 (BD2): 4 nM; BRD4 (BD2): 3 nM; BRDT (BD2): 18 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 94 mg/mL (191.22 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

ABBV-744 is utilized to study the selective inhibition of the BET family of bromodomains, particularly in the context of therapeutic applications in cancer.