Epigenetic reader domain inhibitor CF53, Purity ≥98%

Synonym: 1808160-52-2; CF 53; CF-53; Epigenetic reader domain inhibitor

CAS Number: 1808160-52-2
Compound CID: 118340554

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

CF53 disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD2-BD1, BRD2 (BD2), BRD3 (BD1), BRD3 (BD2), BRD4 (BD1), BRD4 (BD1), BRD4 (BD1), BRD4 (BD2), BRDT (BD1), BRDT (BD2), and CECR2.

Molecular Weight

443.51

Molecular Formula

C₂₄H₂₅N₇O₂

Targets

BRD2-BD1: 1.1 nM (Kd); BRD2 (BD2): 0.6 nM (Kd); BRD3 (BD1): 0.52 nM (Kd); BRD3 (BD2): 0.49 nM (Kd); BRD4 (BD1): <1 nM (Ki); BRD4 (BD1): 2 nM; BRD4 (BD1): 2.2 nM (Kd); BRD4 (BD2): 0.8 nM (Kd); BRDT (BD1): 2 nM (Kd); BRDT (BD2): 1 nM (Kd); CECR2: 570 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

CF53 can be used to research the inhibition of the BET family of proteins in cancer therapy.