Epigenetic reader domain inhibitor dBET57, Purity ≥98%

Synonym: 1883863-52-2; dBET 57; dBET-57; Epigenetic reader domain inhibitor

CAS Number: 1883863-52-2
Compound CID: 118912822

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

dBET57, soluble in DMSO and ethanol and insoluble in water, disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BRD4 (BD1).

Molecular Weight

699.18

Molecular Formula

C₃₄H₃₁ClN₈O₅S

Targets

BRD4 (BD1): 500 nM (DC50)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 89 mg/mL (127.29 mM); Water: Insoluble; Ethanol: 11 mg/mL (15.73 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

dBET57 can be used to investigate targeted protein degradation strategies for BET proteins in cancer research.

Storage

Store at -20ºC.