Epigenetic reader domain inhibitor GSK2801, Purity ≥98%

Synonym: 1619994-68-1; GSK-2801; GSK 2801; Epigenetic reader domain inhibitor

CAS Number: 1619994-68-1
Compound CID: 73010930

Product Size

10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GSK2801, soluble in warmed DMSO and warmed ethanol and insoluble in water, disrupts the function of proteins that recognize and bind specific epigenetic marks, affecting the interpretation of epigenetic signals. It targets BAZ2A and BAZ2B.

Molecular Weight

371.54

Molecular Formula

C₂₀H₂₁NO₄S

Targets

BAZ2A: 257 nM (Kd); BAZ2B: 136 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 67 mg/mL (180.37 mM); Water: Insoluble; Warmed ethanol: 6 mg/mL (16.15 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

GSK2801 can be used to study the inhibition of BAZ2A and BAZ2B bromodomains in cancer and epigenetics.

Storage

Store at -20ºC.