The reprogramming of cancer glucose metabolism is regulated by various mechanisms, such as changes in the tumor microenvironment, oncogenic mutations, and dysregulation of cancer glucose metabolism enzymes. Epigenetics is a collective term for heritable mechanisms that regulate gene expression without altering the DNA sequence, including DNA methylation, histone modifications, chromatin remodeling, non-coding RNAs, etc. Cancer glucose metabolism is closely related to changes at the epigenetic level, and epigenetic mechanisms regulate cancer glucose metabolism by affecting the expression of glucose metabolism-related genes. CD BioGlyco can provide analysis of the effect of cancer glucose metabolites as cofactors on the activity of epigenetic modification enzymes and the analysis of epigenetic modification regulation of cancer glucose metabolism.
The complex interplay between epigenetics and cancer glucose metabolism can be mainly divided into two categories. One is that metabolic small molecules in cancer cells act as cofactors for epigenetic modification enzymes, modification donors, agonists, or antagonists. The other type is that epigenetic modification directly changes the expression of glucose metabolism-related enzymes, transporters, signal transduction, transcription factors, etc., thereby regulating the glucose metabolism of cancer cells.
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The methylation level of cancer glucose metabolism-related genes can regulate the expression of cancer glucose metabolism-related enzymes to regulate glucose metabolism pathways and promote cancer progression.
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Histone modifications can mediate a variety of biological processes including reprogramming of glucose metabolism. For example, acetylases can act as energy and redox sensors by controlling the acetylation status of histones and non-histone proteins. Therefore, studying the relationship between histone modifications and glucose metabolism reprogramming can bring new opportunities for targeted therapy of cancer glucose metabolism.
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Chromatin remodeling is an important modification in the epigenetic regulation of cancer glucose metabolism, which determines the gene transcription and cell fate of cells. Therefore, the study of the relationship between chromatin remodeling and cancer glucose metabolism is indispensable information for the development of epigenetic-based cancer therapeutic strategies.
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CD BioGlyco can provide analytical services related to DNA methylation, histone modification, chromatin remodeling, and other processes involved in the regulation of cancer glucose metabolism. Our experienced teams of scientists, researchers, and technicians provide fast turnaround, high-quality services at competitive prices for worldwide customers. Our customers have direct access to our staff and prompt feedback on their inquiries. If you are interested in our services, please contact us for more details.
