ERK inhibitor FR 180204, Purity ≥98%

Synonym: 865362-74-9; FR 180204; FR-180204; ERK inhibitor II; 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE; 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-2H-pyrazolo[3,4-c]pyridazin-3-amine; ERK inhibitor

MDL: MFCD14585805
CAS Number: 865362-74-9
Compound CID: 11493598

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

FR 180204, soluble in DMSO and warmed ethanol and insoluble in water, exhibits potent inhibition of ERK kinase. It targets ERK2 and ERK1.

Molecular Weight

327.34

Molecular Formula

C₁₈H₁₃N₇

Targets

ERK2: 0.14 μM (Ki); ERK1: 0.31 μM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 57 mg/mL (174.13 mM); Water: Insoluble; Warmed ethanol: 2 mg/mL (6.1 mM)

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

FR180204 can be applied to investigate the inhibition of ERK1/2 activity in cellular signaling research.

Storage

Store at -20ºC.