ERK inhibitor GDC0994, Purity ≥98%

Synonym: Ravoxertinib; GDC-0994; 1453848-26-4; GDC0994; (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one; ERK inhibitor

MDL: MFCD28143918
CAS Number: 1453848-26-4
Compound CID: 71727581

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GDC0994, soluble in DMSO and ethanol and insoluble in water, exhibits potent inhibition of ERK kinase. It targets ERK2 and ERK1.

Molecular Weight

440.87

Molecular Formula

C₂₁H₁₈ClFN₆O₂

Targets

ERK2: 0.3 nM; ERK1: 1.1 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 83 mg/mL (188.7 mM); Water: Insoluble; Ethanol: 83 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

GDC0994 can be utilized to explore the therapeutic potential of ERK1/2 inhibition in oncology.