Cat. No.: X23-10-ZQ866
ERK inhibitor Pluripotin, Purity ≥98%
Synonym: Pluripotin; 839707-37-8; N-(3-(7-(1,3-Dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide; SC1(Pluripotin); CHEMBL4213673; N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide; ERK inhibitor
- MDL: MFCD20527253
- CAS Number: 839707-37-8
- Compound CID: 12003241
Product Size
5 mg; 10 mg; 25 mg; 50 mg; 100 mg
Properties
Description
Pluripotin, soluble in DMSO and insoluble in ethanol and water, exhibits potent inhibition of ERK kinase. It targets ERK1 and RasGAP.
Molecular Formula
C27H25F3N8O2
Targets
ERK1: 98 nM (Kd); RasGAP: 212 nM (Kd)
Solubility
DMSO: 96 mg/mL (174.37 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
Pluripotin can be used to maintain the pluripotency of embryonic stem cells via dual inhibition of ERK1/2 and GSK3 pathways.
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