ERK inhibitor Pluripotin, Purity ≥98%

Synonym: Pluripotin; 839707-37-8; N-(3-(7-(1,3-Dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide; SC1(Pluripotin); CHEMBL4213673; N-(3-(7-((1,3-Dimethyl-1H-pyrazol-5-yl)amino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide; ERK inhibitor

MDL: MFCD20527253
CAS Number: 839707-37-8
Compound CID: 12003241

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Pluripotin, soluble in DMSO and insoluble in ethanol and water, exhibits potent inhibition of ERK kinase. It targets ERK1 and RasGAP.

Molecular Weight

550.5

Molecular Formula

C₂₇H₂₅F₃N₈O₂

Targets

ERK1: 98 nM (Kd); RasGAP: 212 nM (Kd)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 96 mg/mL (174.37 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Pluripotin can be used to maintain the pluripotency of embryonic stem cells via dual inhibition of ERK1/2 and GSK3 pathways.

Storage

Store at -20ºC.