ERK inhibitor TCS ERK 11e, Purity ≥98%

Synonym: VX-11E; 896720-20-0; Vertex-11E; VTX-11E; TCS ERK 11E; 4-[2-(2-Chloro-4-fluoroanilino)-5-methylpyrimidin-4-yl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide; ERK inhibitor

CAS Number: 896720-20-0
Compound CID: 11634725

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

TCS ERK 11e, soluble in DMSO and ethanol and insoluble in water, exhibits potent inhibition of ERK kinase. It targets ERK2, GSK3, AURA, and CDK2.

Molecular Weight

500.35

Molecular Formula

C₂₄H₂₀Cl₂FN₅O₂

Targets

ERK2: <2 nM (Ki); GSK3: 400 nM (Ki); AURA: 540 nM (Ki); CDK2: 850 nM (Ki)

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 94 mg/mL (187.87 mM); Water: Insoluble; Ethanol: 15 mg/mL (29.97 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

TCS ERK 11e can be used to study the selective inhibition of ERK1/2 in signal transduction pathways.