Erythromycin Analysis Service

Analyzing Erythromycin with Precision and Expertise

Erythromycin, an organic compound with the chemical formula C₃₇H₆₇NO₁₃, is a macrolide antibiotic. Erythromycin is a macrolide antibiotic with excellent anti-infective properties and is often used in medical applications in the form of extended-release capsules, extended-release tablets, gels, solutions, injections, granules, or ointments.

At CD BioGlyco, we have advanced Pharmaceutical Analysis technology to provide systematic and professional erythromycin analysis services to clients.

Specific rotation
The erythromycin is dissolved and diluted in anhydrous ethanol and its specific rotation is determined using a spinometer. The specific spin should be between -71° and -78°.
Identification
The infrared spectrum of the sample is tested and the infrared spectrum obtained is compared with the infrared spectrum of the erythromycin standard. If the plots agree, the sample is erythromycin.
Alkalinity
We will dissolve the erythromycin in water and then test its pH, which should be 8.0 to 10.5.
Thiocyanate content
Ultraviolet-visible spectrophotometry: The amount of thiocyanate is obtained by measuring the absorbance of erythromycin solution after dissolving erythromycin in methanol. It is worth noting that the content of thiocyanate in erythromycin should not exceed 0.3%.
Moisture
Moisture of erythromycin is determined using a moisture meter coupled with a Kahlsch drying oven. Erythromycin should not contain more than 6.0% moisture.
Cauterization of residue
Erythromycin is accurately weighed and placed in a crucible followed by slow incandescence until the erythromycin is completely charred. After cooling, it is weighed accurately.
Erythromycin content
The erythromycin is dissolved using methanol, followed by its dilution using phosphate buffer. Finally, it is detected using high-performance liquid chromatography (HPLC). The content of erythromycin can be calculated using the external standard method.

In addition, erythromycin is used in the pharmaceutical field through erythromycin delayed-release capsules, erythromycin topical gel, erythromycin intramammary infusion, erythromycin injection, erythromycin ointment, erythromycin pledgets, erythromycin ophthalmic ointment, erythromycin topical solution, erythromycin tablets, erythromycin delayed-release tablets, erythromycin and benzoyl peroxide topical gel. CD BioGlyco utilizes the above analysis methods and also provides analysis services to its clients.

Fig.1 Erythromycin Analysis Services. (CD BioGlyco)

Publication Data

Technology: Anaerobic fermentation technology

Journal: International Journal of Environmental Research and Public Health

IF: 4.614

Published: 2022

Results: In this research, the authors developed a method for the removal of erythromycin using anaerobic fermentation techniques. In the research, authors explored the removal of erythromycin and its effect mechanism on anaerobic fermentation. Results showed that erythromycin removal was higher than 90% for all tested concentrations after fermentation. In addition, the authors found that the increase in erythromycin content facilitated the inhibition of biogas production. This also proved that erythromycin was able to inhibit the hydrolysis process in the early stage of anaerobic fermentation. The erythromycin was also able to inhibit the lignocellulose degradation in the later stages of fermentation. This study supports the reuse of antibiotic-contaminated biowaste and provides a reference for further research.

Fig.2 Experimental flow chart. (Zhang, et al., 2022)

Advantages

We have an experienced pharmaceutical analysis team to provide custom pharmaceutical analysis services to our clients.
We analyze pharmaceuticals in various aspects, such as physicochemical properties and biological activities, to ensure that we assist our clients in solving the difficult problems encountered in their research.
With our world-leading pharmaceutical analysis technology, we not only provide comprehensive analysis of Pharmaceutical and Biological but also provide detailed data interpretation to our clients.

Relying on state-of-the-art equipment and technology, CD BioGlyco provides high-quality, custom pharmaceutical analysis services. Our research team includes scientists from both pharmacy and biology to ensure that pharmaceutical analysis is done efficiently and effectively for our clients. If you are interested in our services, please feel free to contact us.

Reference

Zhang, H.Y.; et al. The removal of erythromycin and its effects on anaerobic fermentation. International Journal of Environmental Research and Public Health. 2022, 19(12): 7256.

This service is for Research Use Only, not intended for any clinical use.