FAK inhibitor NVP-TAE 226, Purity ≥98%

Synonym: 761437-28-9; FAK inhibitor; TAE226; TAE 226

MDL: MFCD12031516
CAS Number: 761437-28-9
Compound CID: 9934347

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

NVP-TAE 226, soluble in DMSO and insoluble in ethanol and water, is a FAK inhibitor that is used to block angiogenesis in diseases such as cancer. It targets FAK, Insulin receptor, c-Abl, c-Met, C-Raf, c-Src, CDK1/CyclinB, FGFR1, FGFR3 (K650E), FLT1, and FLT3.

Molecular Weight

468.94

Molecular Formula

C₂₃H₂₅ClN₆O₃

Targets

FAK: 5.5 nM; Insulin receptor: 43.5 nM; c-Abl: 5.85 nM; c-Met: 160 nM; C-Raf: >10 μM; c-Src: 905 nM; CDK1/CyclinB: 540 nM; FGFR1: 750 nM; FGFR3 (K650E): 630 nM; FLT1: 3.4 nM; FLT3: 480 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (198.32 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

NVP-TAE 226 is a FAK inhibitor used to understand its role in cancer cell survival and metastasis.