FAK inhibitor PF-00562271, Purity ≥98%

Synonym: 939791-38-5; FAK inhibitor; PF00562271; PF 00562271

MDL: MFCD14105612
CAS Number: 939791-38-5
Compound CID: 16118986

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

PF-00562271, soluble in warmed DMSO and insoluble in water and ethanol, is a FAK inhibitor that is used to block angiogenesis in diseases such as cancer. It targets CDK2/CyclinE, PYK2, Abl, Aurora A, c-Src, CDK1/CyclinB, CDK2/CyclinA, CDK3/CyclinE, CDK4, and CDK5/p35.

Molecular Weight

665.66

Molecular Formula

C₂₁H₂₀F₃N₇O₃S.C₆H₆O₃S

Targets

CDK2/CyclinE: 30 nM; PYK2: 13 nM; Abl: >1 μM; AuroraA: 145 nM; c-Src: 797 nM; CDK1/CyclinB: 58 nM; CDK2/CyclinA: 227 nM; CDK3/CyclinE: 47 nM; CDK4: >1 μM; CDK5/p35: 120 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 14 mg/mL (21.03 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

PF-00562271 is used in the investigation of FAK’s involvement in cancer progression and metastases by specifically blocking its kinase activity.