Farnesyl transferase inhibitor, Lonafarnib, Purity ≥98%

Synonym: 193275-84-2; Sarasar; SCH 66336; SCH66336; SCH-66336; 4-[2-[4-[(2R)-6,15-Dibromo-13-chloro-4-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,12,14-hexaen-2-yl]piperidin-1-yl]-2-oxoethyl]piperidine-1-carboxamide; Farnesyl transferase inhibitor

CAS Number: 193275-84-2
Compound CID: 148195

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Lonafarnib, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting farnesyl transferase. The molecular weight of the compound is 638.82, and its molecular formula is C₂₇H₃₁Br₂ClN₄O₂. It targets the H-ras (Cell-free assay), K-ras-4B (Cell-free assay) and N-ras (Cell-free assay).

Molecular Weight

638.82

Molecular Formula

C₂₇H₃₁Br₂ClN₄O₂

Targets

H-ras (Cell-free assay)

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 116 mg/mL (181.58 mM); Water: insoluble; Ethanol: 116 mg/mL (181.58 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Lonafarnib can be studied extensively for its potential therapeutic applications in the treatment of viral infections like Hutchinson-Gilford progeria syndrome.