Ferroptosis inhibitor, RSL3, Purity ≥98%

Synonym: 1219810-16-8; 1S,3R-RSL3; 1S,3R)-RSL3; RSL3 (1S,3R-); Methyl (1S,3R)-2-(2-chloroacetyl)-1-(4-methoxycarbonylphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-3-carboxylate; Ferroptosis inhibitor

CAS Number: 1219810-16-8
Compound CID: 1750826

Product Size

5 mg; 10 mg; 25 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

RSL3, soluble in DMSO and ethanol and insoluble in water, is an effective metabolism inhibitor, that has the ability to prevent the pathway of cell metabolism by inhibiting ferroptosis. The molecular weight of the compound is 440.88, and its molecular formula is C₂₃H₂₁ClN₂O₅.

Molecular Weight

440.88

Molecular Formula

C₂₃H₂₁ClN₂O₅

Form

Lyophilized powder

Purity

≥98%

Impurities

Free from inappropriate visible particulates, foreign matter, discoloration, or other defects.

Solubility

In vitro: DMSO: 82 mg/mL (185.99 mM); Water: insoluble; Ethanol: 20 mg/mL; In vivo: 2% DMSO + 30% PEG 300 + 2% Tween 80 + ddH₂O, 1 mg/mL

Identity

Confirmed by NMR/HPLC/MS.

Applications

RSL3 plays a key role in inhibiting GPX4, an enzyme that reduces lipid hydroperoxides.