FGFR inhibitor AP24534, Purity ≥98%

Synonym: 943319-70-8; FGFR inhibitor; Ponatinib

MDL: MFCD17215203
CAS Number: 943319-70-8
Compound CID: 24826799

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AP24534, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets PDGFRα, VEGFR2, Abl, Aurora A, c-Kit, c-Src, CDK2/CyclinE, FGFR1, IGF-1R, and Insulin receptor.

Molecular Weight

532.6

Molecular Formula

C₂₉H₂₇F₃N₆O

Targets

PDGFRα: 1.1 nM; VEGFR2: 1.5 nM; Abl: 0.37 nM; AuroraA: >1 μM; c-Kit: 12.5 nM; c-Src: 5.4 nM; CDK2/CyclinE: >1 μM; FGFR1: 2.2 nM; IGF-1R: >1 μM; Insulin receptor: >1 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 30 mg/mL (56.33 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AP24534 is used to inhibit FGFR and study its contribution to targeted cancer therapy.