FGFR inhibitor AZD4547, Purity ≥98%

Synonym: 1035270-39-3; FGFR inhibitor; AZD-4547

MDL: MFCD22580423
CAS Number: 1035270-39-3
Compound CID: 51039095

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

AZD4547, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR2, FGFR3, Akt1, ALK1, Axl, CDK2, FAK, FGFR1, FGFR4, and IGFR.

Molecular Weight

463.6

Molecular Formula

C₂₆H₃₃N₅O₃

Targets

FGFR2: 2.5 nM; FGFR3: 1.8 nM; Akt1: >100 μM; ALK1: >100 μM; Axl: >2 μM; CDK2: >10 μM; FAK: >10 μM; FGFR1: 0.2 nM; FGFR4: 165 nM; IGFR: 581 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 79 mg/mL (170.41 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

AZD4547 targets FGFR signaling pathways, crucial in the study of certain aggressive cancers.