FGFR inhibitor BGJ398, Purity ≥98%

Synonym: 872511-34-7; FGFR inhibitor; BGJ-398

MDL: MFCD22123241
CAS Number: 872511-34-7
Compound CID: 53235510

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

BGJ398, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR2, FGFR3, Abl, FGFR1, FGFR3 (K650E), FGFR4, Fyn, Kit, LCK, Lyn, and VEGFR2.

Molecular Weight

560.48

Molecular Formula

C₂₆H₃₁Cl₂N₇O₃

Targets

FGFR2: 1.4 nM; FGFR3: 1.0 nM; Abl: 2.3 nM; FGFR1: 0.9 nM; FGFR3 (K650E): 4.9 nM; FGFR4: 60 nM; Fyn: 1.9 μM; Kit: 0.75 μM; LCK: 2.5 μM; Lyn: 0.30 μM; VEGFR2: 0.18 μM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 1 mg/mL (1.78 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

BGJ398 is employed as an FGFR inhibitor, offering avenues for research into targeted cancer therapies.