FGFR inhibitor Bibf1120, Purity ≥98%

Synonym: 928326-83-4; FGFR inhibitor; Bibf-1120; Nintedanib; Vargatef

MDL: MFCD11974012
CAS Number: 928326-83-4
Compound CID: 135423438

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Bibf1120, soluble in DMSO and ethanol and insoluble in water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, and VEGFR3.

Molecular Weight

539.6

Molecular Formula

C₃₁H₃₃N₅O₄

Targets

FGFR1: 69 nM; FGFR2: 37 nM; FGFR3: 108 nM; PDGFRα: 59 nM; PDGFRβ: 65 nM; VEGFR1: 34 nM; VEGFR2: 13 nM; VEGFR3: 13 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 6 mg/mL (11.11 mM); Water: Insoluble; Ethanol: 3 mg/mL (5.55 mM)

Identity

Confirmed by NMR/HPLC/MS.

Applications

Bibf1120 is applied to inhibit FGFR, focusing on its significance in cancer proliferation.