Properties
Description
BLU9931, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR3, and FGFR4.
Molecular Formula
C26H22Cl2N4O3
Targets
FGFR1: 591 nM; FGFR2: 493 nM; FGFR3: 150 nM; FGFR4: 3 nM
Solubility
Warmed DMSO: 4 mg/mL (7.85 mM); Water: Insoluble; Ethanol: Insoluble
Identity
Confirmed by NMR/HPLC/MS.
Applications
BLU9931 serves as an FGFR inhibitor to aid in understanding and potentially inhibiting FGFR aberrant signaling in cancers.
