FGFR inhibitor Danusertib, Purity ≥98%

Synonym: 827318-97-8; Danusertib; PHA-739358; Danusertib (PHA-739358); PHA 739358; Danusertib [INN]; (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; FGFR inhibitor

MDL: MFCD12024692
CAS Number: 827318-97-8
Compound CID: 11442891

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Danusertib, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets VEGFR3, Aurora A, Aurora B, AuroraC, FGFR1, RET, and TrkA.

Molecular Weight

474.6

Molecular Formula

C₂₆H₃₀N₆O₃

Targets

VEGFR3: 46 nM; Aurora A: 13 nM; Aurora B: 79 nM; AuroraC: 61 nM; FGFR1: 47 nM; RET: 31 nM; TrkA: 31 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (195.97 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Danusertib can be studied for its ability to inhibit Aurora kinases and its effects on cell division in cancer research.