FGFR inhibitor Danusertib, Purity ≥98%

Synonym: 827318-97-8; Danusertib; PHA-739358; Danusertib (PHA-739358); PHA 739358; Danusertib [INN]; (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide; FGFR inhibitor

MDL: MFCD12024692
CAS Number: 827318-97-8
Compound CID: 11442891

Product Size

5 mg; 10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Danusertib, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets VEGFR3, Aurora A, Aurora B, AuroraC, FGFR1, RET, and TrkA.

Molecular Weight

474.6

Molecular Formula

C₂₆H₃₀N₆O₃

Targets

VEGFR3: 46 nM; Aurora A: 13 nM; Aurora B: 79 nM; AuroraC: 61 nM; FGFR1: 47 nM; RET: 31 nM; TrkA: 31 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 93 mg/mL (195.97 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Stability

The product is stable for three years when stored at the recommended temperature in lyophilized powder.

Applications

Danusertib can be studied for its ability to inhibit Aurora kinases and its effects on cell division in cancer research.

Storage

Store at -20ºC.