FGFR inhibitor Dovitinib lactate, Purity ≥98%

Synonym: 692737-80-7; FGFR inhibitor; CHIR-258 lactate; CHIR258; CHIR 258; TKI-258 lactate; TKI258; TKI 258

MDL: MFCD23103506
CAS Number: 692737-80-7
Compound CID: 135431668

Product Size

5 mg; 10 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Dovitinib lactate is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets c-Kit, CSF-1R, FGFR1, FGFR3, FLT3, PDGFRα, PDGFRβ, VEGFR1, VEGFR2, and VEGFR3.

Molecular Weight

482.51

Molecular Formula

C₂₄H₂₇FN₆O₄

Targets

c-Kit: 2 nM; CSF-1R: 36 nM; FGFR1: 8 nM; FGFR3: 9 nM; FLT3: 1 nM; PDGFRα: 210 nM; PDGFRβ: 27 nM; VEGFR1: 10 nM; VEGFR2: 13 nM; VEGFR3: 8 nM

Form

Lyophilized powder

Purity

≥98%

Identity

Confirmed by NMR/HPLC/MS.

Applications

Dovitinib lactate is used in research to inhibit FGFR, advancing the understanding of FGFR’s involvement in cancer, especially for tumors with abnormal FGFR signaling.