FGFR inhibitor Futibatinib, Purity ≥98%

Synonym: 1448169-71-8; FGFR inhibitor; TAS-120; TAS120; TAS 120

CAS Number: 1448169-71-8
Compound CID: 71621331

Product Size

1 mg; 5 mg; 10 mg; 50 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

Futibatinib, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets FGFR1, FGFR2, FGFR2 E566G, FGFR2 N550H, FGFR2 V5651, FGFR3, FGFR4, and wild-type FGFR2.

Molecular Weight

418.45

Molecular Formula

C₂₂H₂₂N₆O₃

Targets

FGFR1: 3.9 nM; FGFR2: 1.3 nM; FGFR2 E566G: 2.4 nM; FGFR2 N550H: 3.6 nM; FGFR2 V5651: 1-3 nM; FGFR3: 1.6 nM; FGFR4: 8.3 nM; wild-type FGFR2: 0.3 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 75 mg/mL (179.23 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

Futibatinib is employed in exploring FGFR as a selective inhibitor, aiding in the development of FGFR-targeted cancer therapies.