FGFR inhibitor GW 786034 HCl, Purity ≥98%

Synonym: 635702-64-6; FGFR inhibitor; GW786034; GW-786034

MDL: MFCD12546138
CAS Number: 635702-64-6
Compound CID: 11525740

Product Size

10 mg; 25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GW786034, soluble in DMSO and insoluble in ethanol and water, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets VEGFR2, VEGFR3, c-Fms, c-Kit, FGFR, PDGFR, and VEGFR1.

Molecular Weight

474

Molecular Formula

C₂₁H₂₃N₇O₂S.HCl

Targets

VEGFR2: 30 nM; VEGFR3: 47 nM; c-Fms: 146 nM; c-Kit: 140 nM; FGFR: 74140 nM; PDGFR: 84 nM; VEGFR1: 10 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

DMSO: 15 mg/mL (31.64 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GW-786034 is used in FGFR research to explore its role as a targeted inhibitor in oncology, enhancing the development of FGFR-targeted therapies.