FGFR inhibitor GW-786034, Purity ≥98%

Synonym: 444731-52-6; FGFR inhibitor; GW 786034; Votrient; GW786034

MDL: MFCD11616589
CAS Number: 444731-52-6
Compound CID: 10113978

Product Size

25 mg; 50 mg; 100 mg

Price

Datasheet

Datasheet

MSDS

MSDS

Properties

Description

GW-786034, soluble in warmed DMSO and insoluble in water and ethanol, is a protein tyrosine kinase inhibitor that has shown potent biochemical activity against FGFR. It targets VEGFR2, VEGFR3, c-Fms, c-Kit, FGFR, PDGFR, and VEGFR1.

Molecular Weight

437.5

Molecular Formula

C₂₁H₂₃N₇O₂S

Targets

VEGFR2: 30 nM; VEGFR3: 47 nM; c-Fms: 146 nM; c-Kit: 140 nM; FGFR: 74140 nM; PDGFR: 84 nM; VEGFR1: 10 nM

Form

Lyophilized powder

Purity

≥98%

Solubility

Warmed DMSO: 84 mg/mL (191.98 mM); Water: Insoluble; Ethanol: Insoluble

Identity

Confirmed by NMR/HPLC/MS.

Applications

GW-786034 (GW786034) is used in FGFR research to explore its role as a targeted inhibitor in oncology, enhancing the development of FGFR-targeted therapies.